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Can you build a CBD tolerance?

Can I use CBD for a long time? And can my body create tolerance towards it? These are the questions you would like to be answered? Frequent use of marijuana can lead to tolerance building where the user needs more and more dosing to get the same effects. Since CBD and THC are virtually cousins, it must naturally be assumed that tolerance can also be created for the CBD. So how is it really?


Explanation of CBD and tolerance

CBD is still not fully explored, but in general we can say "no" in this matter. The use of CBD does not lead to tolerance. The opposite is true. The use of CBD often leads to reverse tolerance.

The reason why CBD can produce reverse tolerance is that it increases natural endocannabinoids. This means that over time, users can reduce their dose and achieve the same results. Thus, CBD (cannabidiol) is the opposite of THC, which in turn reduces cannabinoid receptors over time. This is why THC users are encouraged to increase their dosage.

This is very noteworthy with regard to CBD and medical aspect (and cost), as patients can reduce their dose, do not need to address a dose increase.

What to do if you feel that you have builded tolerance

Let's say you are using CBD for seven months and you feel that you are no longer achieving the desired results. Now what?

Apparently, you are the first to think of increasing the dose - which will probably work, but we recommend a different option.

The estimated CBD time spent in the human body is between 18-32 hours, so try to skip the use of CBDs for at least two days and then start using it again and try a little lower dose.

For more information on how to properly dose CBD, check out our article: CBD – less is sometimes more.


Further research is needed to confirm the "reverse tolerance" hypothesis, but evidence suggests that CBD users may not be afraid of tolerance. This is really remarkable, especially given the wide range of CBD healing effects; Many of the issues they are dealing with are currently being treated with heavy medicines, which themselves constitute tolerance. Lack of CBD tolerance is another convincing point in favor of this miraculous cannabinoid.

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NEW ORLEANS - Cannabis oil extract with cannabidiol ratio (CBD) 20: 1 to tetrahydrocannabinol (THC) can reduce seizures in children and adults with treatment resistant epilepsy, but according to the study, a quarter of the patients developed tolerance.

"CBD is a good choice for children and adults with certain types of epilepsy, but as with antiepileptic drugs, it may be less effective over time and dosage may need to be increased to cope with seizures," said Shimrit Uliel-Sibony, MD, lead author of the study and leader pediatric epilepsy child services at Dana-Dwek Children's Hospital in Tel Aviv Sourasky Medical Center.

Previous studies have found that cannabinoid efficacy can be reduced when used to treat pain. Efficacy also decreases in animals with seizures.

To assess cannabinoid tolerance in the treatment of children and adults with epilepsy, researchers in Israel conducted a prospective review of 92 patients with epilepsy resistant to treatment. Patients were 1-37 years old (mean age, 11.8 years) and were treated with hemp oil extract from 1 March 2014 to 1 December December. Researchers have defined tolerance as the need to increase the dose by at least 30% after a reduction in efficacy or a more than 30% reduction in treatment response.

Patients had various forms of epilepsy (eg, Dravet's syndrome, Lennox-Gastaut's syndrome, and stroke-induced epilepsy) and an average of 19.8 months of used hemp oil extract. Of the 84 patients included in the tolerance analysis, 21 patients (25%) developed tolerance on average 7.3 months (range 1-24 months) at an average dose of 12.6 mg / kg daily. After the patients with tolerance received an increased dose, 4 patients returned to their earlier response levels and 10 patients had a response that was "satisfactory but below the [previous] level of response," said Dr. Uliel-Sibony and colleagues.

Approximately one third of patients discontinued treatment due to side effects or lack of efficacy. Side effects included drowsiness, nausea, decreased appetite, and vomiting. In addition, two patients worsened seizures and one patient had signs of psychosis; treatment was discontinued immediately in these three patients.

The researchers had no information and received no funding for this study.



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All presented hemp products are 100% legal according to EU legislation. They are made from legal agricultural strains of hemp which contain the legal level of THC (less than 0,2%). Hemp seed is used for the production of oil, protein and also for direct consumption. Hemp herb is used for CBD extraction, tea, and ointments & cosmetics. All our products are NOT psychoactive. offers a complete range of hemp, CBD products & foods. All EU mostly organic production. 

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