CB2 Receptors: The Forgotten Key to Body and Immunity Balance

Author: Lucie Garabasova

CB2 receptors have been the stars of the world of science, health and natural medicine in recent years. While their "siblings" CB1 receptors are known for their binding to THC and their effects in the brain, CB2 receptors deserve attention mainly for their ability to regulate immune responses, inflammation and pain. And this is where the direct or indirect activity of CBD (cannabidiol) and BCP (beta-caryophyllene) also intervenes.

What are CB2 receptors and where can we find them?

CB2 are a type of receptor of the endocannabinoid system (ECS), which ensures balance or homeostasis in the body. While CB1 receptors are mainly found in the brain, CB2 receptors can be found:

• in immune cells,
• in the digestive tract,
• in the spleen,
• in the lungs,
• in the skin,
• in muscles, joints and bones.

CB2 receptors are activated especially in cases of inflammation, infection or injury. Their main task? Suppressing inflammatory processes and maintaining balance in the immune system.

How does CBD affect CB2 receptors?

CBD, or cannabidiol, does not activate CB2 receptors directly, but affects their function indirectly through a number of mechanisms. It supports the production of endocannabinoids (e.g. 2-AG), which bind directly to CB2.

Thanks to this, CBD can:

• reduce chronic and acute inflammation,
• contribute to the regulation of autoimmune processes,
• relieve pain associated with inflammation,
• improve regeneration after injury and pain.

CBD is therefore a suitable supplement for those who suffer from, for example, arthritis, eczema, allergies or inflammatory diseases of the digestive tract.

BCP: A terpene that targets CB2 directly

Beta-caryophyllene (BCP) is a terpene commonly found in cannabis, black pepper, cloves or rosemary. However, compared to CBD, BCP is unique in that it directly activates CB2 receptors.

This means:

• strong anti-inflammatory effects,
• analgesic (pain-relieving) effects,
• protection of nerve cells (neuroprotection),
• support of a healthy immune system response.

BCP is therefore becoming a frequent component of advanced cannabis products such as full-spectrum CBD oils, ointments or dietary  supplements.

CB2 receptors in animals

CB2 receptors are not just a privilege of the human body. Dogs, cats, horses and rodents also have them. This is why active substances such as CBD and BCP are also used in veterinary care - for joint pain, inflammation or skin problems.

CBD + BCP: An ideal synergistic combination

While CBD changes the functioning of the entire endocannabinoid system and supports its balance, BCP directly activates CB2 receptors. Their combination brings a strong anti-inflammatory, regenerative and protective effect.

What does science have to say?

Yes, there are a number of scientific studies that deal with CB2 receptors and their potential in medicine. Below I list some key research:

🧪 Important studies on CB2 receptors

1. CB2 receptors and inflammatory diseases
   A study published in the journal Molecules examined the role of CB2 receptors in the regulation of the immune response and inflammatory processes. The results suggest that activation of CB2 receptors may have therapeutic potential in the treatment of inflammatory diseases.
2. CB2 Receptors and Neurodegenerative Diseases
   A study published in Frontiers in Pharmacology focused on the expression and function of CB2 receptors in human leukocytes. The study highlights the need for a deeper understanding of CB2 receptors as immunoregulatory elements in humans.
3. Beta-caryophyllene (BCP) as a selective CB2 receptor agonist
   A review published in Biomedicine & Pharmacotherapy focused on the pharmacological properties and therapeutic potential of BCP, which selectively activates CB2 receptors. The research suggests that BCP may be effective in treating various pathological conditions through the activation of CB2 receptors.
4. CB2 Receptors and Food Intake Regulation
   A systematic review published in the International Journal of Molecular Sciences analyzed the role of CB2 receptors in the regulation of food intake. The study suggests that CB2 receptors may play a role in modulating food intake and energy balance.
5. CB2 Receptors and Cardioprotection
   Research published in the International Journal of Molecular Sciences looked at the role of CB2 receptors in cardiomyocytes. The study found that CB2 receptor activation may play a key role in alleviating the pathological changes associated with myocardial infarction.

These studies point to the broad therapeutic potential of CB2 receptors in various areas of medicine, including the treatment of inflammatory diseases, neurodegenerative disorders, food intake regulation, and cardioprotection. If you are interested in specific areas or additional information, I am happy to provide a more detailed overview.

Summary: Why monitor CB2 receptors

They are key to balancing the immune system.
Activating CB2 can help with pain, inflammation, and regeneration.
CBD affects their function indirectly, BCP directly.
Their stimulation is not associated with any psychoactive effects.