Cannabigerol (CBG) is one of many substances known as cannabinoids that occur in hemp plants. CBG exists in lower concentrations than THC or CBD. These other cannabinoids have been somewhat shaded for a long time. In recent years, however, scientific interest in CBG has grown steadily. In this article, we will examine CBG in more detail and also will
How does CBG work in our body?
Like other cannabinoids, CBG works by affecting the endocannabinoid system in our body. The endocannabinoid system is a complex set of receptors (CB1 and CB2 receptors), chemicals called endocannabinoids and enzymes.
Endocannabinoids are compounds that our body produces. They bind to CB1 and CB2 receptors. Their role is to help regulate many of our physiological functions and maintain a state of internal balance.
CB1 receptors are primarily in the nervous system and brain. CB2 receptors are anywhere in the body, especially in cells of the immune system. Many different endocannabinoids can bind to these receptors, but the best known are anandamide (AEA) and 2-arachidonoylglycerol (2-AG).
AEA binds primarily to CB1 receptors and acts very similarly to a neurotransmitter, affecting our cognitive function and mood. On the other hand, 2-AG binds to CB1 and CB2 receptors, which produces an anti-inflammatory effect.
Cannabinoids in the hemp plant can also bind to these receptors due to their similar shape.
Research has shown that CBG binds primarily to CB2 receptors.
This complex interaction between various plant cannabinoids and the endocannabinoid system in the body is called the "entourage effect". Scientists are just beginning to understand the full implications of this. However, some have suggested that the use of these cannabinoids in combination is more advantageous than the use of any alone.
What is CBG used for?
We still do not fully understand the benefits of CBG. However, initial research suggests that it may be a useful tool in a wide range of physical and mental conditions. Let's take a look at existing research on CBG and how it could affect your health.
Anti-inflammatory effects of CBG
CBG appears to have anti-inflammatory properties. Therefore, it could potentially help in the treatment of many different chronic diseases.
One study on CBG for inflammatory bowel disease (IBD) yielded interesting results. The researchers found that CBG reduced inflammatory markers in mice with induced IBD and alleviated colitis. Based on these findings, the study authors suggest that CBG should be further tested in human subjects as a treatment for IBD.
It is therefore highly desirable to find new ways to reduce inflammation to prevent and help with these potentially fatal conditions. Although more research is needed, cannabinoids, including CBG (Cannabigerol), could offer one such hope.
Neuroprotective effects of CBG
In addition to its anti-inflammatory effects, CBG can also act as an antioxidant and protect the nervous system from damage. It does this in a similar way to the endocannabinoid 2-AG.
Another animal study on the neuroprotective effects of CBG yielded some interesting results. It has been found that CBG can help improve motor deficits and preserve neurons in neurodegenerative diseases such as Huntington's disease.
CBG as an appetite stimulator
CBG also shows great promise as an appetite stimulator, as researchers discovered in a 2016 study on CBG for appetite. They gave the rats either CBG or a placebo and observed their eating habits. Rats that ate CBG increased their number of meals and doubled their total food intake. However, the amount consumed with food and the length of food were not affected.
The researchers found no adverse effects in CBG-treated rats. This could potentially make this cannabinoid a promising therapy for conditions such as anorexia and cachexia.
CBG for bladder problems
A 2015 study of cannabinoids for bladder dysfunction found that they are able to reduce acetylcholine-induced bladder contractions in mice. Among all the cannabinoids tested, CBG was one of the most effective, along with 99-tetrahydrocannabivarin (THCV). CBG has also been shown to reduce these contractions in human subjects.
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