Alternative to CBD? Try PEA

In this article you will learn:

• PEA - what is it?
• How does PEA work?
• Does PEA have any side effects?
• How can be PEA used and where to find it?

PEA - what is it?

Monoethanolamide of palmitic acid, abbreviated PEA, is a chemical endogenous compound, which means it occurs naturally in the body. It is formed by a reaction between palmitic acid and monoethanolamine. Palmitic acid is a fatty acid found in many natural fats, such as palm nut oil or coconut oil.
PEA was first isolated and identified in 1957 in the Netherlands. Dutch scientist Dr. J.J. Hesselink isolated this substance from nuts and named it palmitoylethanolamide.

Monoethanolamine (MEA) is an organic compound that contains an amine and a hydroxyl group. The reaction between palmitic acid and monoethanolamine produces an ester that can be used in cosmetic and pharmaceutical products.

PEA is mainly used for its properties that can have a positive effect on pain and inflammation, you can find it in dietary supplements or cosmetics (creams).

How does PEA work?

Monoethanolamide of palmitic acid (PEA) is mainly associated with anti-inflammatory and analgesic effects, mainly through interaction with the endocannabinoid system (similar to CBD products).

Mechanisms of action of PEA:

• Interaction with the endocannabinoid system: PEA may interact with the endocannabinoid system, which plays a role in the regulation of inflammation, pain and other physiological processes.
• Stabilization of cell membranes: PEA may affect membrane stability and integrity, which may influence signaling pathways and inflammatory processes.
• Inhibition of mast cell activation: Mast cells are cells closely associated with allergic and inflammatory reactions. PEA may have an inhibitory effect on the activation of these cells.
• Modulation of the immune response: PEA may influence the immune response by regulating the production of inflammatory mediators.
• Interaction with peroxisomal receptors: PEA may interact with peroxisomal receptors (PPARs), which are nuclear receptors that regulate gene expression and may play a role in inflammation.

Studies on palmitic acid monoethanolamide

As already mentioned, PEA was discovered in the 1950s. Research has therefore been going on for almost 80 years.

A study on PEA and neuropathy: In all patients who completed this study, PEA treatment significantly reduced the mean pain intensity score as assessed by a numeric scale. The effect of PEA was independent of the pathological condition associated with the pain. The reduction in pain intensity induced by PEA was also present in patients without concomitant analgesic treatment. Importantly, PEA showed no adverse effects.

• Name of the study: "Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis."
• Authors: A. Esposito, S. Bianco, R. R. Pironti, et al.

Research on PEA and inflammatory diseases and the analgesic effects of PEA: The study confirms that PEA improves experimental colitis in animals, with this effect mediated by CB2, GPR55 and PPARα receptors and modulated by TRPV1 channels.

• Name of the study: "Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent."
• Authors: G. D'Argenio, G. Petrosino, P. Gianfrani, et al.

Synaptic effects of palmitoylethanolamide in neurodegenerative disorders: In the last few years, palmitoylethanolamide (PEA), an endogenous lipid mediator, and its novel composite, a formulation consisting of PEA and the well-known antioxidant flavonoid luteolin (Lut), which has undergone an ultra micronization process (co-ultraPEALut), have been identified as a potential therapeutic agent in a variety of disorders by having potential beneficial effects on neurodegeneration and neuroinflammation through modulation of synaptic transmission.

• Name of the study: "Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders."
• Authors: Martina Assogna , Francesco Di Lorenzo, Alessandro Martorana, Giacomo Koch

Studies on PEA and nervous system protection: The results of this study show that PEA treatment leads to a reduction in the number of infiltrating astrocytes during Aβ challenge, resulting in significant neuroprotection. Thus, PEA could represent a promising pharmacological tool because it can reduce Aβ-induced neuroinflammation and mitigate its neurodegenerative consequences.

• Name of the study: "Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α."
• Authors: T. R. Grösch, M. Hermanns, K. W. Klein, et al.

Does PEA have any side effects?

Although there are several studies examining PEA, there is not yet a large enough amount of data to definitively and unequivocally determine the side effects. In general, most people tolerate PEA well, and side effects are usually mild and rare. Possible side effects include nausea, headache, or indigestion. However, each person may react differently, so it is always best to consult a doctor before starting any new supplement or treatment, including PEA.

How can be PEA used and where to find it?

Monoethanolamide palmitic acid (PEA) can be found in dietary supplements, specifically, we would like to introduce you to the Endostar line. The products Endostar Fit and Endostar Relax, combine natural ingredients, with PEA being one of the main active ingredients of the dietary supplement. The FIT product is designed especially for those who are looking for a quality preparation for the regeneration of the body, while Relax supports more emotional and physical states to achieve internal balance.

Let's take a closer look at the products.

What is Endostar FIT and what are its effects?

Endostar Fit capsules contain PEA as the main ingredient, they also contain edestin, sea buckthorn extract, turmeric, and Camu Camu. The capsules are recommended to be taken for the regeneration of the body, and also during the recovery period. It is therefore suitable after injuries, after surgery, and in times of increased stress. Thanks to the PEA contained, they help relieve pain and inflammation and protect the nervous system.

The dosage is very simple, it is recommended 1 capsule 3 times a day with meals.

What is Endostar Relax and what are its effects?

Endostar Relax is an innovative dietary supplement that is particularly suitable for those who feel irritable and stressed and want to calm the mind, improve sleep quality, and reduce anxiety. The ingredients of the product are coriander and clove extract, PEA, and also Oleoylethanolamide (OEA) - which is a substance known as an endocannabinoid.

 The dosage is similar to the FIT product, i.e. 1 capsule 3 times a day.