PEA: The Promising Alternative to CBD for Pain and Inflammation Relief
Article author: Ondrej Stovicek
Looking for a gentle alternative to CBD or CBD drops? Palmitoylethanolamide (PEA for short) is a substance naturally produced by the body, which may be of interest to you, especially because it can gently support the body during long-term discomfort, strain, and recovery.
- PEA is a naturally occurring substance in the body – a natural “internal helper”.
- It is not derived from hemp, but it is connected to the body's internal balance system.
- In supplements, it is used to support strain, recovery, and overall comfort.
PEA (palmitoylethanolamide) – an alternative for those seeking gentle support
In this article, you will learn:
What is palmitoylethanolamide?
PEA stands for palmitoylethanolamide. It is a naturally occurring substance in the body that is found in the human organism. Simply put, the body produces it as part of its “protective system,” especially when under stress or strain.
The compound was first identified in 1957 and has since been the subject of numerous studies. In dietary supplements, it is mainly used as a gentle support for long-term discomfort, inflammatory processes, and overexertion.
During long-term stress, fatigue, or after an injury, the body may have lower levels of this substance – which is why some people choose to supplement it in capsule form.
How does PEA work in the body?
Palmitoylethanolamide is a substance that the body produces as a natural “protective response” when something is out of balance – for example, during pain, irritation, or inflammation.
Simply put, it works by:
- helping the body calm excessive inflammatory responses,
- supporting the protection of nerve cells,
- and contributing to the body's ability to better cope with long-term discomfort.
It can be described as a gentle “internal regulator” that helps the body return to balance.
Why is it considered an alternative to CBD?
This substance is linked to the so-called endocannabinoid system – an internal system that influences pain, inflammation, and the body's stress response.
Unlike CBD, however, it is not derived from hemp but is a naturally occurring molecule produced by the body itself.
What do studies say?
Research on this substance has been ongoing for decades. It was first described by scientists in 1957, and clinical studies have been conducted since the 1970s. Below are several more recent examples:
1) Chronic pain
In a study where PEA was administered, a significant reduction in pain intensity was observed, with minimal adverse effects reported.
- Title: Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis
- Link: https://pubmed.ncbi.nlm.nih.gov/22845893/
2) Inflammatory processes (experimental model)
The study describes the anti-inflammatory effects of PEA in an experimental animal model.
- Title: Palmitoylethanolamide… intestinal anti-inflammatory agent
- Link: https://pubmed.ncbi.nlm.nih.gov/25205418/
3) Nervous system (synaptic effects)
A review study describes a potential relationship between PEA, neuroinflammation, and synaptic transmission.
- Title: Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders
- Link: https://pubmed.ncbi.nlm.nih.gov/36009055/
4) Neuroprotection (experimental model)
The study describes neuroprotective effects in a laboratory model.
- Title: Palmitoylethanolamide exerts neuroprotective effects… via PPAR-α
- Link: https://pubmed.ncbi.nlm.nih.gov/22405189/
Does PEA have side effects?
In general, this substance is considered to be well tolerated. If side effects occur, they are usually mild and rare (e.g., nausea, headache, or digestive discomfort).
How should products containing PEA be used?
Always follow the recommended dosage provided for the specific product. Generally, the effects tend to be gradual and depend on consistent use.
We especially recommend:
- taking it regularly,
- ideally with food (depending on the product),
- not exceeding the recommended dosage.
Where can you find palmitoylethanolamide – Zelená Země products
This naturally occurring substance is most commonly found in dietary supplements. At Zelená Země, we have developed capsules tailored to specific needs:
PEA FIT Capsules – Recovery and Vitality
Suitable during fatigue, recovery periods, and sports activities. Gentle support for the body's regeneration.
PEA Relax Capsules – Calmness and Mental Well-Being
For periods of stress and tension. Supports relaxation and inner balance.