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Cbd Can Help Doctors Reduce The Dose Of Chemotherapy


A new technique from Israel uses cannabidiol to open a channel for drugs targeting only cancer cells, potentially allowing a finer chemotherapy course.



Scientists led by Professor Alexander Binshtok, head of the Pain Plasticity Research Group at the Hebrew University of Jerusalem, have developed a method that delivers chemotherapy drugs directly to malignant cells and bypasses healthy cells.

Doctors could potentially use this method to reduce doses of chemotherapy for patients, resulting in less unpleasant side effects and improving treatment compliance and overall prognosis.

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"Most anti-cancer treatments are not specific enough, which means they attack healthy cells along with the malignant ones they try to get rid of," - Binshtok explained.

“This leads to many serious side effects associated with chemotherapy. Removing cancer cells while leaving healthy cells is an important step in reducing patient suffering,” - he said.

Binshtok and his team in Frontiers in Pharmacology described how they used cannabidiol (CBD) and another agent to activate a protein called TRPV2 to open a channel inside liver cancer cell membranes. They then injected a low dose of doxorubicin into the canal and directly into the cancer cells.

Doxorubtion In The Cancer Cells

They discovered that "cell death mediated by doxorubicin is significantly more effective when co-administered with CBD and requires a significantly lower dose."

"It is too early for concrete predictions, but we hope this discovery will lead to a new, more targeted delivery method for chemotherapy that drastically reduces patient pain," - Binshtok concluded.

The participating scientists were Hagit Neumann-Raziel, Asaf Shilo, Shaya Lev, Maxim Mogilevsky, Ben Katz, David Shneor, Yoav D. Shaul, Alberto Gabizon, Rotem Karni and Alik Honigman of Hebrew University and Andreas Leffler of Hanover Medical School in Germany. 

Resourse: https://www.israel21c.org/cbd-could-help-doctors-use-lower-doses-of-chemotherapy/



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